In the first clinical trial of reducose XR, or mulberry leaf extract, published in the prestigious Journal of Clinical Investigation, published in May 2021, a total of 612 people with diabetes were randomly assigned to take a daily supplement consisting of either a single tablet or four pills that contained a blend of stabilized Olean liquid extract, stearic acid, and xantham gum. At the end of the six-week study period, researchers reported that there was a significant improvement in the levels of plasma insulin and HbA1c in the treated group compared to the placebo group. The white mulberry extract was also reported to have anti-diabetic properties. In a subsequent double-blinded, randomized, controlled clinical trial, published in the prestigious Journal of Clinical Investigation, Reducose XR, a single tablet of xanthan gum was again found to significantly lower postprandial decreases in plasma glucose and insulin in diabetic subjects after the intake of sucrose.

These results indicate that there are substantial improvements when it comes to the control of blood glucose levels even in the presence of a sugar-free diet. The improvement in insulin sensitivity is most likely due to the ability of theophylline to reduce inflammation, which can reduce cell damage and increase blood flow to injured cells. The combination of reduced inflammation and increased blood flow may be able to explain the results of the placebo group who showed no significant changes from the initial visit compared to those in the group receiving the extract. It is, however, important to note that the degree of improvement observed may not be clinically relevant given that the subjects taking the extract already had a considerable improvement in their blood sugar levels at the start of the study. Furthermore, it should be noted that there was no difference between the treatment groups in the total number of weight losses and that the amount of weight loss achieved by the subjects in the placebo group was significantly greater than the gains achieved by those in the treatment group.